Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Nkx2-1  NK2 homeobox 1   (Synonyms: T/EBP, thyroid-specific enhancer-binding protein, thyroid transcription factor-1, tinman, Titf1, Ttf-1)
Results	Reference
1	J:288305 Aslanpour S, Rosin JM, Balakrishnan A, Klenin N, Blot F, Gradwohl G, Schuurmans C, Kurrasch DM, Ascl1 is required to specify a subset of ventromedial hypothalamic neurons. Development. 2020 May 28;147(10):dev180067
1	J:276488 Bilodeau M, Shojaie S, Ackerley C, Post M, Rossant J, Identification of a proximal progenitor population from murine fetal lungs with clonogenic and multilineage differentiation potential. Stem Cell Reports. 2014 Oct 14;3(4):634-49
1	J:339096 Biswas S, Chan CS, Rubenstein JLR, Gan L, The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus. Dev Biol. 2023 Aug 1;503:10-24
1	J:185338 Boucherat O, Chakir J, Jeannotte L, The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways. Biol Open. 2012;q:677-691
1	J:239777 Boucherat O, Landry-Truchon K, Berube-Simard FA, Houde N, Beuret L, Lezmi G, Foulkes WD, Delacourt C, Charron J, Jeannotte L, Epithelial inactivation of Yy1 abrogates lung branching morphogenesis. Development. 2015 Sep 01;142(17):2981-95
1*	J:193583 Cai Y, Zhang Q, Wang C, Zhang Y, Ma T, Zhou X, Tian M, Rubenstein JL, Yang Z, Nuclear receptor COUP-TFII-expressing neocortical interneurons are derived from the medial and lateral/caudal ganglionic eminence and define specific subsets of mature interneurons. J Comp Neurol. 2013 Feb 1;521(2):479-97
1	J:213234 Cho HH, Cargnin F, Kim Y, Lee B, Kwon RJ, Nam H, Shen R, Barnes AP, Lee JW, Lee S, Lee SK, Isl1 directly controls a cholinergic neuronal identity in the developing forebrain and spinal cord by forming cell type-specific complexes. PLoS Genet. 2014 Apr;10(4):e1004280
1	J:269807 Correa SM, Newstrom DW, Warne JP, Flandin P, Cheung CC, Lin-Moore AT, Pierce AA, Xu AW, Rubenstein JL, Ingraham HA, An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females. Cell Rep. 2015 Jan 6;10(1):62-74
1	J:321833 Del Aguila A, Adam M, Ullom K, Shaw N, Qin S, Ehrman J, Nardini D, Salomone J, Gebelein B, Lu QR, Potter SS, Waclaw R, Campbell K, Nakafuku M, Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice. Development. 2022 Mar 1;149(5):dev200028
1	J:227081 Delgado RN, Lim DA, Embryonic Nkx2.1-expressing neural precursor cells contribute to the regional heterogeneity of adult V-SVZ neural stem cells. Dev Biol. 2015 Nov 15;407(2):265-74
1	J:207468 Desai TJ, Brownfield DG, Krasnow MA, Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature. 2014 Mar 13;507(7491):190-4
1	J:144755 Di Palma T, D'Andrea B, Liguori GL, Liguoro A, de Cristofaro T, Del Prete D, Pappalardo A, Mascia A, Zannini M, TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation. Exp Cell Res. 2009 Jan 15;315(2):162-75
1	J:342610 Didier-Mathon H, Stoupa A, Kariyawasam D, Yde S, Cochant-Priollet B, Groussin L, Sebag F, Cagnard N, Nitschke P, Luton D, Polak M, Carre A, Borealin/CDCA8 deficiency alters thyroid development and results in papillary tumor-like structures. Front Endocrinol (Lausanne). 2023;14:1286747
1	J:332091 Ding W, Zhang C, Wang B, Zhou X, Sun L, Zhong S, Liu J, Zhang J, Wang X, Wu Q, Loss of the centrosomal protein Cenpj leads to dysfunction of the hypothalamus and obesity in mice. Sci China Life Sci. 2021 Mar;64(3):419-433
1*	J:84816 Fagman H, Grande M, Edsbagge J, Semb H, Nilsson M, Expression of classical cadherins in thyroid development: maintenance of an epithelial phenotype throughout organogenesis. Endocrinology. 2003 Aug;144(8):3618-24
1	J:157830 Flandin P, Kimura S, Rubenstein JL, The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons. J Neurosci. 2010 Feb 24;30(8):2812-23
1	J:174967 Flandin P, Zhao Y, Vogt D, Jeong J, Long J, Potter G, Westphal H, Rubenstein JL, Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors. Neuron. 2011 Jun 9;70(5):939-50
1	J:181140 Frezzetti D, Reale C, Cali G, Nitsch L, Fagman H, Nilsson O, Scarfo M, De Vita G, Di Lauro R, The microRNA-processing enzyme Dicer is essential for thyroid function. PLoS One. 2011;6(11):e27648
1	J:163224 Garcia-Lopez M, Abellan A, Legaz I, Rubenstein JL, Puelles L, Medina L, Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development. J Comp Neurol. 2008 Jan 1;506(1):46-74
1	J:282733 Gerlini R, Amendola E, Conte A, Valente V, Tornincasa M, Credendino SC, Cammarota F, Gentile C, Di Guida L, Paladino S, De Vita G, Fusco A, Pierantoni GM, Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice. Cell Death Dis. 2019 Oct 3;10(10):747
1*	J:248980 Guo H, Kazadaeva Y, Ortega FE, Manjunath N, Desai TJ, Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung. Dev Biol. 2017 Oct 1;430(1):214-223
1	J:270164 Guo M, Du Y, Gokey JJ, Ray S, Bell SM, Adam M, Sudha P, Perl AK, Deshmukh H, Potter SS, Whitsett JA, Xu Y, Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. Nat Commun. 2019 Jan 3;10(1):37
1	J:302122 Guo SS, Seiwert A, Szeto IYY, Fassler R, Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins. Exp Cell Res. 2021 Jan 1;398(1):112391
1*	J:243650 Herriges MJ, Tischfield DJ, Cui Z, Morley MP, Han Y, Babu A, Li S, Lu M, Cendan I, Garcia BA, Anderson SA, Morrisey EE, The NANCI-Nkx2.1 gene duplex buffers Nkx2.1 expression to maintain lung development and homeostasis. Genes Dev. 2017 May 01;31(9):889-903
1	J:306316 Hou Y, Zhang Q, Liu H, Wu J, Shi Y, Qi Y, Shao M, Yang Z, Lu J, Wu Z, Gong L, He M, Topographical organization of mammillary neurogenesis and efferent projections in the mouse brain. Cell Rep. 2021 Feb 9;34(6):108712
1	J:135241 Izvolsky KI, Lu J, Martin G, Albrecht KH, Cardoso WV, Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis. Genesis. 2008 Jan;46(1):8-18
1	J:224337 Jia Z, Guo Y, Tang Y, Xu Q, Li B, Wu Q, Regulation of the protocadherin Celsr3 gene and its role in globus pallidus development and connectivity. Mol Cell Biol. 2014 Oct;34(20):3895-910
1*	J:316194 Jimenez FR, Lewis JB, Belgique ST, Wood TT, Reynolds PR, Developmental lung expression and transcriptional regulation of claudin-6 by TTF-1, Gata-6, and FoxA2. Respir Res. 2014 Jun 26;15:70
1	J:338359 Kaur N, Han W, Li Z, Madrigal MP, Shim S, Pochareddy S, Gulden FO, Li M, Xu X, Xing X, Takeo Y, Li Z, Lu K, Imamura Kawasawa Y, Ballester-Lurbe B, Moreno-Bravo JA, Chedotal A, Terrado J, Perez-Roger I, Koleske AJ, Sestan N, Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold. Neuron. 2020 Sep 23;107(6):1197-1211.e9
1	J:326523 Kheirollahi V, Khadim A, Kiliaris G, Korfei M, Barroso MM, Alexopoulos I, Vazquez-Armendariz AI, Wygrecka M, Ruppert C, Guenther A, Seeger W, Herold S, El Agha E, Transcriptional Profiling of Insulin-like Growth Factor Signaling Components in Embryonic Lung Development and Idiopathic Pulmonary Fibrosis. Cells. 2022 Jun 20;11(12)
1	J:268349 Kim HT, Yin W, Jin YJ, Panza P, Gunawan F, Grohmann B, Buettner C, Sokol AM, Preussner J, Guenther S, Kostin S, Ruppert C, Bhagwat AM, Ma X, Graumann J, Looso M, Guenther A, Adelstein RS, Offermanns S, Stainier DYR, Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease. Nat Commun. 2018 Nov 2;9(1):4600
1	J:282804 Kim HT, Yin W, Nakamichi Y, Panza P, Grohmann B, Buettner C, Guenther S, Ruppert C, Kobayashi Y, Guenther A, Stainier DYR, WNT/RYK signaling restricts goblet cell differentiation during lung development and repair. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25697-25706
1	J:287368 Kim-Muller JY, Fan J, Kim YJ, Lee SA, Ishida E, Blaner WS, Accili D, Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic beta cells in diabetic mice. Nat Commun. 2016 Aug 30;7:12631
1	J:111027 Kusakabe T, Kawaguchi A, Hoshi N, Kawaguchi R, Hoshi S, Kimura S, Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid. Mol Endocrinol. 2006 Aug;20(8):1796-809
1	J:318015 Lange AW, Sridharan A, Xu Y, Stripp BR, Perl AK, Whitsett JA, Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung. J Mol Cell Biol. 2015 Feb;7(1):35-47
1	J:339853 Li S, Liberti D, Zhou S, Ying Y, Kong J, Basil MC, Cardenas-Diaz FL, Shiraishi K, Morley MP, Morrisey EE, DOT1L regulates lung developmental epithelial cell fate and adult alveolar stem cell differentiation after acute injury. Stem Cell Reports. 2023 Aug 8;
1	J:293339 Liang S, Johansson E, Barila G, Altschuler DL, Fagman H, Nilsson M, A branching morphogenesis program governs embryonic growth of the thyroid gland. Development. 2018 Jan 25;145(2):dev146829
1	J:74531 Liu C, Glasser SW, Wan H, Whitsett JA, GATA-6 and Thyroid Transcription Factor-1 Directly Interact and Regulate Surfactant Protein-C Gene Expression. J Biol Chem. 2002 Feb 8;277(6):4519-25
1	J:181392 Londhe VA, Maisonet TM, Lopez B, Jeng JM, Xiao J, Li C, Minoo P, Conditional deletion of epithelial IKKbeta impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis. Respir Res. 2011;12:134
1*	J:287785 Longmire TA, Ikonomou L, Hawkins F, Christodoulou C, Cao Y, Jean JC, Kwok LW, Mou H, Rajagopal J, Shen SS, Dowton AA, Serra M, Weiss DJ, Green MD, Snoeck HW, Ramirez MI, Kotton DN, Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell. 2012 Apr 6;10(4):398-411
1	J:241923 Lopez IP, Pineiro-Hermida S, Pais RS, Torrens R, Hoeflich A, Pichel JG, Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation. PLoS One. 2016;11(11):e0166388
1	J:193919 Lu F, Kar D, Gruenig N, Zhang ZW, Cousins N, Rodgers HM, Swindell EC, Jamrich M, Schuurmans C, Mathers PH, Kurrasch DM, Rax is a selector gene for mediobasal hypothalamic cell types. J Neurosci. 2013 Jan 2;33(1):259-72
1*	J:128019 Lu Y, Thomson JM, Wong HY, Hammond SM, Hogan BL, Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Dev Biol. 2007 Oct 15;310(2):442-53
1	J:219800 Lungova V, Verheyden JM, Herriges J, Sun X, Thibeault SL, Ontogeny of the mouse vocal fold epithelium. Dev Biol. 2015 Mar 15;399(2):263-82
1	J:306212 Ma T, Wong SZH, Lee B, Ming GL, Song H, Decoding neuronal composition and ontogeny of individual hypothalamic nuclei. Neuron. 2021 Apr 7;109(7):1150-1167.e6
1	J:254523 Magno L, Barry C, Schmidt-Hieber C, Theodotou P, Hausser M, Kessaris N, NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory. Cell Rep. 2017 Aug 15;20(7):1572-1584
1	J:184343 Magno L, Kretz O, Bert B, Ersozlu S, Vogt J, Fink H, Kimura S, Vogt A, Monyer H, Nitsch R, Naumann T, The integrity of cholinergic basal forebrain neurons depends on expression of Nkx2-1. Eur J Neurosci. 2011 Dec;34(11):1767-82
1	J:227683 Marin O, Anderson SA, Rubenstein JL, Origin and molecular specification of striatal interneurons. J Neurosci. 2000 Aug 15;20(16):6063-76
1	J:220108 Marotta P, Amendola E, Scarfo M, De Luca P, Zoppoli P, Amoresano A, De Felice M, Di Lauro R, The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells. Mol Cell Endocrinol. 2014 Oct;396(1-2):26-36
1	J:275078 Minocha S, Valloton D, Arsenijevic Y, Cardinaux JR, Guidi R, Hornung JP, Lebrand C, Nkx2.1 regulates the generation of telencephalic astrocytes during embryonic development. Sci Rep. 2017 Mar 7;7:43093
1*	J:54641 Minoo P, Su G, Drum H, Bringas P, Kimura S, Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos. Dev Biol. 1999 May 1;209(1):60-71
1	J:264719 Moghieb A, Clair G, Mitchell HD, Kitzmiller J, Zink EM, Kim YM, Petyuk V, Shukla A, Moore RJ, Metz TO, Carson J, McDermott JE, Corley RA, Whitsett JA, Ansong C, Time-resolved proteome profiling of normal lung development. Am J Physiol Lung Cell Mol Physiol. 2018 Jul 1;315(1):L11-L24
1	J:66247 Naltner A, Wert S, Whitsett JA, Yan C, Temporal/spatial expression of nuclear receptor coactivators in the mouse lung. Am J Physiol Lung Cell Mol Physiol. 2000 Dec;279(6):L1066-74
1	J:157829 Nobrega-Pereira S, Gelman D, Bartolini G, Pla R, Pierani A, Marin O, Origin and molecular specification of globus pallidus neurons. J Neurosci. 2010 Feb 24;30(8):2824-34
1	J:332133 Nunnelly LF, Campbell M, Lee DI, Dummer P, Gu G, Menon V, Au E, St18 specifies globus pallidus projection neuron identity in MGE lineage. Nat Commun. 2022 Dec 14;13(1):7735
1	J:183999 Ouseph MM, Li J, Chen HZ, Pecot T, Wenzel P, Thompson JC, Comstock G, Chokshi V, Byrne M, Forde B, Chong JL, Huang K, Machiraju R, de Bruin A, Leone G, Atypical E2F repressors and activators coordinate placental development. Dev Cell. 2012 Apr 17;22(4):849-62
1	J:217594 Plosa EJ, Young LR, Gulleman PM, Polosukhin VV, Zaynagetdinov R, Benjamin JT, Im AM, van der Meer R, Gleaves LA, Bulus N, Han W, Prince LS, Blackwell TS, Zent R, Epithelial beta1 integrin is required for lung branching morphogenesis and alveolarization. Development. 2014 Dec;141(24):4751-62
1	J:176239 Pombero A, Bueno C, Saglietti L, Rodenas M, Guimera J, Bulfone A, Martinez S, Pallial origin of basal forebrain cholinergic neurons in the nucleus basalis of Meynert and horizontal limb of the diagonal band nucleus. Development. 2011 Oct;138(19):4315-26
1	J:122951 Ramasamy SK, Mailleux AA, Gupte VV, Mata F, Sala FG, Veltmaat JM, Del Moral PM, De Langhe S, Parsa S, Kelly LK, Kelly R, Shia W, Keshet E, Minoo P, Warburton D, Bellusci S, Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development. Dev Biol. 2007 Jul 15;307(2):237-47
1*	J:170419 Reynolds PR, Allison CH, Willnauer CP, TTF-1 regulates alpha5 nicotinic acetylcholine receptor (nAChR) subunits in proximal and distal lung epithelium. Respir Res. 2010;11:175
1	J:338817 Schoultz E, Liang S, Carlsson T, Filges S, Stahlberg A, Fagman H, Wiel C, Sayin V, Nilsson M, Tissue specificity of oncogenic BRAF targeted to lung and thyroid through a shared lineage factor. iScience. 2023 Jul 21;26(7):107071
1	J:295090 Stoupa A, Adam F, Kariyawasam D, Strassel C, Gawade S, Szinnai G, Kauskot A, Lasne D, Janke C, Natarajan K, Schmitt A, Bole-Feysot C, Nitschke P, Leger J, Jabot-Hanin F, Tores F, Michel A, Munnich A, Besmond C, Scharfmann R, Lanza F, Borgel D, Polak M, Carre A, TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology. EMBO Mol Med. 2018 Dec;10(12)
1	J:115581 Tian J, Mahmood R, Hnasko R, Locker J, Loss of Nkx2.8 deregulates progenitor cells in the large airways and leads to dysplasia. Cancer Res. 2006 Nov 1;66(21):10399-407
1	J:55155 Tichelaar JW, Wert SE, Costa RH, Kimura S, Whitsett JA, HNF-3/forkhead homologue-4 (HFH-4) is expressed in ciliated epithelial cells in the developing mouse lung. J Histochem Cytochem. 1999 Jun;47(6):823-32
1*	J:141842 Tomita T, Kido T, Kurotani R, Iemura S, Sterneck E, Natsume T, Vinson C, Kimura S, CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression. J Biol Chem. 2008 Sep 12;283(37):25617-27
1	J:213914 Tong CK, Han YG, Shah JK, Obernier K, Guinto CD, Alvarez-Buylla A, Primary cilia are required in a unique subpopulation of neural progenitors. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12438-43
1	J:83384 Tran PV, Lee MB, Marin O, Xu B, Jones KR, Reichardt LF, Rubenstein JR, Ingraham HA, Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventromedial hypothalamic neurons. Mol Cell Neurosci. 2003 Apr;22(4):441-53
1	J:234401 Tsao PN, Matsuoka C, Wei SC, Sato A, Sato S, Hasegawa K, Chen HK, Ling TY, Mori M, Cardoso WV, Morimoto M, Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity. Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8242-7
1*	J:217271 Varma S, Cao Y, Tagne JB, Lakshminarayanan M, Li J, Friedman TB, Morell RJ, Warburton D, Kotton DN, Ramirez MI, The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation. J Biol Chem. 2012 Oct 26;287(44):37282-95
1	J:297253 Vila Ellis L, Cain MP, Hutchison V, Flodby P, Crandall ED, Borok Z, Zhou B, Ostrin EJ, Wythe JD, Chen J, Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung. Dev Cell. 2020 Mar 9;52(5):617-630.e6
1	J:265679 Wang B, Joo JH, Mount R, Teubner BJW, Krenzer A, Ward AL, Ichhaporia VP, Adams EJ, Khoriaty R, Peters ST, Pruett-Miller SM, Zakharenko SS, Ginsburg D, Kundu M, The COPII cargo adapter SEC24C is essential for neuronal homeostasis. J Clin Invest. 2018 Aug 1;128(8):3319-3332
1	J:84053 Wang T, Tamakoshi T, Uezato T, Shu F, Kanzaki-Kato N, Fu Y, Koseki H, Yoshida N, Sugiyama T, Miura N, Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate. Dev Biol. 2003 Jul 1;259(1):83-94
1*	J:56404 Wani MA, Wert SE, Lingrel JB, Lung Kruppel-like factor, a zinc finger transcription factor, is essential for normal lung development. J Biol Chem. 1999 Jul 23;274(30):21180-5
1	J:192502 Wei B, Huang Z, He S, Sun C, You Y, Liu F, Yang Z, The onion skin-like organization of the septum arises from multiple embryonic origins to form multiple adult neuronal fates. Neuroscience. 2012 Oct 11;222:110-23
1	J:266389 Yin W, Kim HT, Wang S, Gunawan F, Wang L, Kishimoto K, Zhong H, Roman D, Preussner J, Guenther S, Graef V, Buettner C, Grohmann B, Looso M, Morimoto M, Mardon G, Offermanns S, Stainier DYR, The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Nat Commun. 2018 Jul 19;9(1):2815
1*	J:35560 Zhou L, Lim L, Costa RH, Whitsett JA, Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung. J Histochem Cytochem. 1996 Oct;44(10):1183-93